Shoot at Andross' eyes until he has to rub them. Then shoot at his hands. If he tries to inhale you, move to the side of the screen. When he spits rocks, keep shooting them. Continue shooting his eyes and then hands and repeat this until his head explodes. If you are fighting the fake Andross, you will find a robot. Just fire a bomb to destroy it. If you are fighting the real Andross, he will turn into a brain. Chase his eyes and destroy them. After destroying both of them, the brain will chase you. When it gets close enough, somersault. If he grabbed you, keep pressing buttons to escape. If done correctly, you will now be behind him. Shoot the gray matter and repeat until he is defeated. After that, follow your father out or you will die.
Alternatively, the following tough and dangerous tactic can be used. First, start shooting the hands. They have a significant level of health -- be persistent and very fast, since they hit hard. When Andross starts the vacuum attack, get to a lower corner, hold Z/R to stay on the side, and hold the brake. If done correctly, you should barely avoid the attack. If you get sucked in, both wings and the laser power-ups will be lost, and you will also descend at a slow rate of speed. Once his hands are gone, he can only execute the suck and spit attacks. Shoot the rocks, avoid the mouth, and shoot his eyes. When he turns into the mechanical form, stay to either side of the screen. Dodge him when he charges, and shoot him when he retreats to finally defeat Andross.
When you get to Andross, destroy his hands. When he tries to vacuum you in, just fire a bomb into his mouth. He will stop and the bomb will cause smoke to shoot out his ears and nose. This does a great deal of damage.
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